Diagnosis of Ehlers-Danlos Syndrome (EDS) is typically made by a specialist physician through a comprehensive physical examination and a thorough review of the patient's medical history. The physician will carefully assess physical signs, particularly examining skin characteristics and joint hypermobility. While EDS has a genetic basis, many individuals with the syndrome may not have an identifiable specific genetic mutation. Consequently, diagnosis primarily relies on the detailed evaluation of clinical symptoms and the patient's medical background.