The treatment of pernicious anemia involves various methods aimed at increasing vitamin B12 absorption. These methods include, at times, the use of antibiotics to balance the intestinal flora, intramuscular injections to address B12 deficiency, and oral B12 supplements. For mild cases, nasal sprays or dietary supplements may be preferred, while in severe cases, B12 support can be provided through intravenous (via vein) or intramuscular (via buttocks) injections.

Furthermore, if there are underlying cardiovascular, neurological, or gastroenterological issues, a combined treatment plan addressing these conditions can be implemented. Throughout the treatment process, the patient's B12 stores are regularly monitored, and lifestyle and dietary changes may be recommended. It is also beneficial to add B12-rich foods such as fish, eggs, milk, cheese, white and red meat to the diet.