Infectious mononucleosis, commonly known as 'kissing disease,' currently lacks a specific antiviral treatment targeting the causative virus. Management primarily focuses on supportive care. Crucial to recovery is strict rest, particularly due to the risk of splenic rupture, which is most prevalent between the second and fourth weeks of the illness. To minimize this risk, especially in young patients, it is imperative to refrain from strenuous physical activities such as dancing and sports for at least four weeks.
Preventing constipation is also important to avoid straining. Symptomatic relief may include fever-reducing medications and throat gargles. Aspirin should not be used. Close medical monitoring and follow-up are essential. In some cases, significantly enlarged tonsils can obstruct the airway and impair breathing; immediate medical consultation is advised if this symptom arises. Weekly close follow-up of patients is recommended. Currently, there is no vaccine available to prevent infectious mononucleosis.