Amyloidosis is a condition characterized by the abnormal folding of proteins in the body, leading to the formation of insoluble fibrils that accumulate in various organs and tissues. These protein deposits can impair the structure and function of the affected organs.

Amyloidosis can develop secondary to an underlying condition, or it can occur without any apparent cause (primary or idiopathic). In some cases, genetic factors may also play a role.

Conditions that can lead to the development of amyloidosis include certain types of cancer (especially multiple myeloma and Hodgkin lymphoma), chronic infections, chronic inflammatory diseases (e.g., Familial Mediterranean Fever), and kidney failure in patients undergoing long-term dialysis.

Amyloidosis is generally more common in individuals aged 50 and over, but it can also appear in different age groups depending on its type.